In the 1989 painting The Calling of Euphrosyne of Polotsk, Sergei Simakov portrayed Predislava Svyatoslavna, the daughter of Svyatoslav Vseslavich, the Prince of Vitebsk. At twelve, having come of age, she refused a dynastic marriage and retired to a monastery. Predislava took the monastic vows under the name of Euphrosyne and settled in a cell of St. Sophia Cathedral in Polotsk. Euphrosyne donated money for the construction of churches and monasteries, copied and possibly translated books, encouraged her sisters to take the veil. She also was one of the most influential enlighteners of the time of the Polotsk Principality. She became the first Russian woman to be canonized.

Above the cathedral, the Virgin is depicted in the image of Hodigitria; it is believed that such an icon was first painted by the disciple of Christ, the apostle and evangelist Luke.

In the right corner of the picture, the scene of the introduction of the Mother of God to the Jerusalem Temple is depicted; thus Simakov compares Euphrosyne’s monastic life to the ascetic life of the Virgin. The holy Hierarch Demetrius of Rostov also noted that the reverend imitated the ancient Jerusalem virgins, among whom the Most Holy Virgin Mary dwelt: she lived in a cubicle attached to the wall of the church.